Economic considerations for the eradication endgame.

Epidemiological, evolutionary, and economic determinants of eradication tails.

Despite modern medical interventions, infectious diseases continue to generate huge socio-economic losses. The benefits of eradicating a disease are therefore high. While successful with smallpox and rinderpest, many other eradication attempts have failed. Eradications require huge and costly efforts, which can be sustained only if sufficient progress can be achieved. While initial successes ar...

Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame

The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized that inactivated poliovirus vaccine (IPV) is incapable of inducing a strong mucosal response on its own, it has recently become clear that IPV...

The Problems with Polio: Toward Eradication

The global health effort to eradicate poliomyelitis (polio) has encountered a number of unforeseen and unpredictable challenges. This article provides a timely review of progress made toward eradication, including the polio vaccines in use, and explores the reasons for delays in eradication target dates. It provides an overview of some of the remaining barriers to eradication and looks toward o...

From Pakistan a line of hope for 'The Polio Eradication and Endgame Strategic Plan 2013-2018'.

Polio Eradication and Endgame Plan - Victory within Grasp.

Since the launch of the Global Polio Eradication Initiative (GPEI) by the World Health Assembly (WHA) in 1988, the number of polio-endemic countries has decreased from 125 to 2 (Afghanistan and Pakistan). To secure the gains and to address the remaining challenges, the GPEI developed the Polio Eradication and Endgame Strategic Plan, 2013-2018 (the Plan), endorsed by all Member States at the WHA...